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Nobel Prize · Science

The 2026 Nobel Prize in Chemistry goes to Henri B. Kagan and Kenso Soai for the reactions in which chemistry picks one of two mirror-image molecules

On 7 October the Royal Swedish Academy of Sciences honored the two “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis”. Living organisms carry only one of the two mirror-image forms of amino acids; in the test tube chemists always got both in equal amounts.

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Your left and right hands are identical, but one does not fit into the other. Amino acids are like hands: each has two mirror-image forms, and in the proteins of your cells there is only one.

Fact

The facts: on 7 October 2026 the Royal Swedish Academy of Sciences awarded the 2026 Nobel Prize in Chemistry to Henri B. Kagan of Université Paris-Sud in France and Kenso Soai of Tokyo University of Science in Japan “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis”. Molecules such as amino acids exist in two forms that are each other’s mirror image, but living organisms contain only one; the chemistry of life is called homochiral, after the Greek words for “same” and “hand”. How such asymmetry could have emerged was long a mystery. When chemists ran reactions that can form both mirror-image molecules, they always obtained equal proportions in the test tube. Kagan took the first decisive step in 1986: a new way of manipulating chemical reactions, which let him create a greater excess of one of the mirror images than had previously been thought possible. Soai took the next: a publication from 1995 describes how he designed the first ever chemical reaction with the potential to be homochiral, and in 2003 he succeeded with a reaction in which only one of the two possible mirror images was formed. The chair of the Nobel Committee for Chemistry, Heiner Linke, says the two provided a solution to a chemical mystery that is over a century old: how homochirality can emerge spontaneously. The prize is 12 million Swedish kronor, shared equally between the two.

Why this goes beyond the textbooks. With drugs that act on living things, only one mirror image has the desired effect. So chemists want to make only that one, and in the test tube they used to get half and half. The Academy writes that their discoveries have been decisive for chemists who design reactions for the manufacture of pharmaceuticals.

“Other than life itself, no one had previously achieved this feat.”

Two steps. Kagan showed you can get more of one hand than was thought possible. Soai went all the way: one hand only.

One sentence of the announcement deserves a precise reading. The Academy writes that the two showed how homochirality can emerge. It does not write that life started this way. That is a different question.

The question is more than a century old. The answer is a reaction that, out of two possible hands, makes only one.

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